Central modulatory neurons control fuel selection in flight muscle of migratory locust.
J Neurosci
; 23(4): 1109-13, 2003 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-12598597
ABSTRACT
Insect flight is one of the most intense and energy-demanding physiological activities. High carbohydrate oxidation rates are necessary for take-off, but, to spare the limited carbohydrate reserves, long-distance flyers, such as locusts, soon switch to lipid as the main fuel. We demonstrate that before a flight, locust muscles are metabolically poised for take-off by the release of octopamine from central modulatory dorsal unpaired median (DUM) neurons, which increases the levels of the potent glycolytic activator fructose 2,6-bisphosphate in flight muscle. Because DUM neurons innervating the flight muscles are active during rest but selectively inhibited during flight, they stimulate carbohydrate catabolism during take-off but tend to decrease muscle glycolysis during prolonged flight. cAMP-dependent protein kinase A is necessary but not sufficient for signal transduction, suggesting parallel control via a calcium-dependent pathway. Locust flight is the first reported instance of a direct and specific involvement of neuronal activity in the control of muscle glycolysis in working muscle during exercise.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Músculo Esquelético
/
Voo Animal
/
Gafanhotos
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
J Neurosci
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Alemanha