Immunity, microbial pathogenesis, and immunophilins: finding the keys, now where are the locks?
Infect Agents Dis
; 1(3): 121-35, 1992 Jun.
Article
em En
| MEDLINE
| ID: mdl-1285413
ABSTRACT
The discovery and clinical use of the immunosuppressants cyclosporin A, FK506, and rapamycin have greatly advanced solid organ and bone marrow transplantation. Though active as antibiotics against a variety of pathogens, their utility has been severely limited by toxicity. Research on the immunophilins, the major binding proteins of these drugs, has given new insights into protein folding and transport as well as mediators of signal transduction in mammalian cells. Microbial immunophilins may also have direct relevance to the intracellular survival of important human pathogens. Defining the mechanisms of enhanced virulence generated by these proteins holds great promise for understanding both the fundamental pathogenesis of these organisms and the immune response generated against them. Such an understanding may provide novel targets for the design of anti-infective agents as well as assist in the development of future immunosuppressives.
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Bases de dados:
MEDLINE
Assunto principal:
Proteínas de Transporte
/
Proteínas de Ligação a DNA
/
Isomerases de Aminoácido
/
Proteínas de Choque Térmico
/
Imunidade
/
Imunossupressores
/
Infecções
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Infect Agents Dis
Assunto da revista:
DOENCAS TRANSMISSIVEIS
Ano de publicação:
1992
Tipo de documento:
Article