Chromatin assembly by DNA-translocating motors.
Nat Rev Mol Cell Biol
; 4(8): 613-20, 2003 Aug.
Article
em En
| MEDLINE
| ID: mdl-12923523
ABSTRACT
Chromatin assembly is required for the duplication of eukaryotic chromosomes and functions at the interface between cell-cycle progression and gene expression. The central machinery that mediates chromatin assembly consists of histone chaperones, which deliver histones to the DNA, and ATP-utilizing motor proteins, which are DNA-translocating factors that act in conjunction with the histone chaperones to mediate the deposition of histones into periodic nucleosome arrays. Here, we describe these factors and propose possible mechanisms by which DNA-translocating motors might catalyse chromatin assembly.
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Bases de dados:
MEDLINE
Assunto principal:
Cromatina
/
Proteínas Motores Moleculares
/
Proteínas de Ligação a DNA
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Rev Mol Cell Biol
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Estados Unidos