Synthesis and biological activity of new quinoxaline antibiotics of echinomycin analogues.
Bioorg Med Chem Lett
; 14(2): 541-4, 2004 Jan 19.
Article
em En
| MEDLINE
| ID: mdl-14698199
ABSTRACT
Novel quinoxaline antibiotics having the methylenedithioether bridge as an analogue of echinomycin have been synthesized by insertion of methylene moiety between -S-S- bond. The compound 1a shows remarkable cytotoxicities against human tumor various cell lines, and is active VRE (vancomycin-resistant enterococci) within MIC range 0.5-8 microg/mL. According to the eukaryotic or prokaryotic data, 1a might be a first analogue to replace echinomycin.
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Bases de dados:
MEDLINE
Assunto principal:
Quinoxalinas
/
Equinomicina
/
Antibacterianos
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Coréia do Sul