A genome-wide screen for genes influencing conduct disorder.
Mol Psychiatry
; 9(1): 81-6, 2004 Jan.
Article
em En
| MEDLINE
| ID: mdl-14699444
ABSTRACT
While behavioral genetic studies have suggested that childhood conduct disorder is under genetic influence, studies aimed at gene identification are lacking. This study represents the first genome-wide linkage analysis directed toward identifying genes contributing to conduct disorder. Genome screens of retrospectively reported childhood conduct disorder and conduct disorder symptomatology were carried out in the genetically informative adult sample collected as part of the Collaborative Study on the Genetics of Alcoholism (COGA). The results suggest that regions on chromosomes 19 and 2 may contain genes conferring risk to conduct disorder. Interestingly, the same region on chromosome 2 has also been linked to alcohol dependence in this sample. Childhood conduct disorder is known to be associated with the susceptibility for future alcohol problems. Taken together, these findings suggest that some of the genes contributing to alcohol dependence in adulthood may also contribute to conduct disorder in childhood.
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Bases de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos Par 1
/
Cromossomos Humanos Par 19
/
Genoma Humano
/
Transtorno da Conduta
/
Escore Lod
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Child
/
Humans
Idioma:
En
Revista:
Mol Psychiatry
Assunto da revista:
BIOLOGIA MOLECULAR
/
PSIQUIATRIA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos