N-[1-Aryl-2-(1-imidazolo)ethyl]-guanidine derivatives as potent inhibitors of the bovine mitochondrial F1F0 ATP hydrolase.
Bioorg Med Chem Lett
; 14(4): 1027-30, 2004 Feb 23.
Article
em En
| MEDLINE
| ID: mdl-15013016
ABSTRACT
A series of substituted guanidine derivatives were prepared and evaluated as potent and selective inhibitors of mitochondrial F(1)F(0) ATP hydrolase. The initial thiourethane derived lead molecules possessed intriguing in vitro pharmacological profiles, though contained moieties considered non-drug-like. Analogue synthesis efforts led to compounds with maintained potency and superior physical properties. Small molecules in this series which potently and selectivity inhibit ATP hydrolase and not ATP synthase may have utility as cardioprotective agents.
Buscar no Google
Bases de dados:
MEDLINE
Assunto principal:
Trifosfato de Adenosina
/
ATPases Mitocondriais Próton-Translocadoras
/
Inibidores Enzimáticos
/
Guanidinas
/
Mitocôndrias
Limite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos