Parathyroid hormone-related peptide is required for increased trabecular bone volume in parathyroid hormone-null mice.
Endocrinology
; 145(8): 3554-62, 2004 Aug.
Article
em En
| MEDLINE
| ID: mdl-15090463
ABSTRACT
We investigated the relative contributions of PTH and PTHrP to the skeletal phenotype of mice deficient in PTH (PTH(-/-)). PTH(-/-) mice and PTH(-/-) mice lacking one allele encoding PTHrP (PTH(-/-)PTHrP(+/-)) were compared. Both mutants displayed similar biochemical abnormalities of hypoparathyroidism, but skeletal PTHrP mRNA and protein were decreased in PTH(-/-)PTHrP(+/ -) mice. PTH(-/-) mice had increased trabecular bone volume with diminished bone turnover. PTHrP haploinsufficiency reduced trabecular bone of the PTH(-/-) mice to levels below those in wild-type animals by decreasing osteoprogenitor cell recruitment, enhancing osteoblast apoptosis, and diminishing bone formation. The results show that the increased trabecular bone volume in PTH-deficient mice is due to diminished PTH-induced osteoclastic bone resorption and persistent PTHrP-stimulated osteoblastic bone formation. They also illustrate the changing role of PTHrP during bone development, demonstrate its bone- forming function in the postnatal state, and support its pharmacological potential as an anabolic agent.
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Bases de dados:
MEDLINE
Assunto principal:
Hormônio Paratireóideo
/
Densidade Óssea
/
Proteína Relacionada ao Hormônio Paratireóideo
Limite:
Animals
Idioma:
En
Revista:
Endocrinology
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Canadá