[Normal pattern of intraepidermal nerve fibers in 30 healthy volunteers with PGP 9.5]. / Padronização normal das fibras nervosas intraepidérmicas em 30 voluntários saudáveis com PGP 9,5.
Arq Neuropsiquiatr
; 62(2A): 271-5, 2004 Jun.
Article
em Pt
| MEDLINE
| ID: mdl-15235730
ABSTRACT
Skin biopsy has become an attractive technique to evaluate the terminal regions of small nerve fibers. There is extensive innervation of the skin by both sensory and autonomic fibers as demonstrated by staining for the pan-axonal marker PGP 9,5. The normal pattern is fundamental before any study, since three different techniques described in the literature with different results. Skin biopsy specimens of 3-mm in diameter were obtained from the distal leg of 30 healthy controls. Median intraepidermal nerve fiber density was 5.3/mm. Skin biopsy may be a useful tool for assessing the topographic extent and degree of nerve fiber damage in sensory neuropathies and may be particularly useful in experimental treatment trials for peripheral neuropathies since, in contrast to standard nerve biopsy, the test can be repeated.
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Bases de dados:
MEDLINE
Assunto principal:
Ubiquitina Tiolesterase
/
Epiderme
/
Fibras Nervosas
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Pt
Revista:
Arq Neuropsiquiatr
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Brasil