Lactoferrin modifies apoptosis-related gene expression in the colon of the azoxymethane-treated rat.
Cancer Lett
; 213(1): 21-9, 2004 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-15312680
ABSTRACT
Lactoferrin, an iron-binding glycoprotein, exhibits suppressive effects on development of azoxymethane (AOM)-induced tumors in the rat colon, but the mechanisms are largely unknown. In this study, we investigated the effect of lactoferrin on the gene expression of 10 apoptosis-related molecules in colon mucosa of AOM-treated rats during early and late stages of colon carcinogenesis by reverse transcription PCR. Here we document that a death-inducing receptor, Fas, and a pro-apoptotic Bcl-2 family member, Bid, are increased in the colon mucosa in proportion to decreases in AOM-induced aberrant crypt foci by lactoferrin. Similarly, increased expression of the pro-apoptotic Bcl-2 family member, Bax, was also observed in AOM-induced tumors in rats fed by lactoferrin. These results indicate that Fas and pro-apoptotic Bcl-2 members participate in the lactoferrin action and may contribute to suppressive effects on tumor development in the rat colon.
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Bases de dados:
MEDLINE
Assunto principal:
Azoximetano
/
Glicoproteínas de Membrana
/
Carcinógenos
/
Regulação da Expressão Gênica
/
Apoptose
/
Neoplasias do Colo
/
Ciclina D1
/
Lactoferrina
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Japão