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A report on single exon genes (SEG) in eukaryotes.

Sakharkar, Meena Kishore; Chow, Vincent Tak Kwong; Chaturvedi, Iti; Mathura, Venkatarajan Subramanian; Shapshak, Paul; Kangueane, Pandjassarame.
Front Biosci ; 9: 3262-7, 2004 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-15353355
Single exon genes (SEG) are archetypical of prokaryotes. Hence, their presence in intron-rich, multi-cellular eukaryotic genomes is perplexing. Consequently, a study on SEG origin and evolution is important. Towards this goal, we took the first initiative of identifying and counting SEG in nine completely sequenced eukaryotic organisms--four of which are unicellular (E. cuniculi, S. cerevisiae, S. pombe, P. falciparum) and five of which are multi-cellular (C. elegans, A. thaliana, D. melanogaster, M. musculus, H. sapiens). This exercise enabled us to compare their proportion in unicellular and multi-cellular genomes. The comparison suggests that the SEG fraction decreases with gene count (r = -0.80) and increases with gene density (r = 0.88) in these genomes. We also examined the distribution patterns of their protein lengths in different genomes.