Dam methylation: coordinating cellular processes.
Curr Opin Microbiol
; 8(2): 154-60, 2005 Apr.
Article
em En
| MEDLINE
| ID: mdl-15802246
ABSTRACT
GATC sequences in Escherichia coli DNA are methylated at the adenine residue by DNA adenine methyltransferase (DamMT). These methylated residues and/or the level of DamMT can influence cellular functions such as gene transcription, DNA mismatch repair, initiation of chromosome replication and nucleoid structure. In certain bacteria, unlike E. coli, DamMT is essential for viability perhaps owing to its role in chromosome replication. DamMT has also been implicated as a virulence factor in bacterial pathogenesis. The origin and phylogeny of DamMT, based on sequenced genomes, has been deduced.
Buscar no Google
Bases de dados:
MEDLINE
Assunto principal:
DNA Bacteriano
/
DNA Metiltransferases Sítio Específica (Adenina-Específica)
/
Regulação Bacteriana da Expressão Gênica
/
Fenômenos Fisiológicos Bacterianos
/
Metilação de DNA
Idioma:
En
Revista:
Curr Opin Microbiol
Assunto da revista:
MICROBIOLOGIA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Dinamarca