Attenuation correction for small animal PET tomographs.
Phys Med Biol
; 50(8): 1837-50, 2005 Apr 21.
Article
em En
| MEDLINE
| ID: mdl-15815099
ABSTRACT
Attenuation correction is one of the important corrections required for quantitative positron emission tomography (PET). This work will compare the quantitative accuracy of attenuation correction using a simple global scale factor with traditional transmission-based methods acquired either with a small animal PET or a small animal x-ray computed tomography (CT) scanner. Two phantoms (one mouse-sized and one rat-sized) and two animal subjects (one mouse and one rat) were scanned in CTI Concorde Microsystem's microPET Focus for emission and transmission data and in ImTek's MicroCAT II for transmission data. PET emission image values were calibrated against a scintillation well counter. Results indicate that the scale factor method of attenuation correction places the average measured activity concentration about the expected value, without correcting for the cupping artefact from attenuation. Noise analysis in the phantom studies with the PET-based method shows that noise in the transmission data increases the noise in the corrected emission data. The CT-based method was accurate and delivered low-noise images suitable for both PET data correction and PET tracer localization.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Algoritmos
/
Interpretação de Imagem Assistida por Computador
/
Aumento da Imagem
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Técnica de Subtração
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Tomografia por Emissão de Pósitrons
Tipo de estudo:
Diagnostic_studies
/
Evaluation_studies
Limite:
Animals
Idioma:
En
Revista:
Phys Med Biol
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos