Synthesis of alpha-L-threofuranosyl nucleoside triphosphates (tNTPs).
Org Lett
; 7(8): 1485-7, 2005 Apr 14.
Article
em En
| MEDLINE
| ID: mdl-15816733
ABSTRACT
[structure see text] The alpha-l-threofuranosyl nucleoside triphosphates of T, G, and D (tTTP, tGTP, and tDTP) were synthesized from the described 2'-O-DMT-protected derivatives using the Eckstein method, while the corresponding C derivative (tCTP) was prepared from the 2'-O-acetyl derivative. The prepared alpha-l-threofuranosyl nucleoside triphosphates, despite being one carbon shorter than the native 2'-deoxyfuranosyl nucleoside triphosphates, are effective substrates for selected DNA polymerases.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
DNA Polimerase Dirigida por DNA
/
Nucleotídeos
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos