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Human genome -- from pieces to patterns.

Sakharkar, Meena Kishore; Kangueane, Pandjassarame; Perumal, Bagavathi S; Chow, Vincent Tak Kwong; Sorscher, Eric; Sakharkar, Kishore R; Hill, Aubrey.
Front Biosci ; 10: 2576-84, 2005 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-15970519
A profile of exon-intron lengths in genes shows a normal distribution. This observation suggests that different genes may have portions of their total exon and/or intron lengths in common. In order to explore the common exon-intron structural patterns that may arise due to common lengths across genes, we compared the exon-intron length patterns of annotated human genes. We discovered 1762278 conserved arrangements of exon-intron length across the otherwise unrelated and diverse genomic landscape. The existence of common exon-intron length patterns across unrelated genes suggests for their role of in gene assemblage and human genome design and architecture.