High levels of nucleotide diversity in the European rabbit (Oryctolagus cuniculus) SRY gene.
Anim Genet
; 36(4): 349-51, 2005 Aug.
Article
em En
| MEDLINE
| ID: mdl-16026347
ABSTRACT
We have sequenced 2,388 bp of the European rabbit sex determining region Y (SRY) gene. These data provide a 10-fold increase in the coverage of the Y chromosome in this species, including the entire open reading frame of the SRY, the polyadenylation signal, and two repetitive sequences in the 5' -region. A survey of 2021 bp of this gene in eight domestic breeds and four wild individuals revealed a total of nine single nucleotide polymorphisms and one indel, defining two deeply divergent lineages. The resulting estimation of nucleotide diversity (pi=1.34 x10(-3)) is very high when compared with other species, but no variability was detected among the domestic breeds. This study represents a first step in the characterization of the European rabbit Y chromosome and its variability. These sequences can be used in additional phylogeographical analyses of the European rabbit and other Leporid species, as well as in evolutionary studies of sex determination and the Y chromosome in wild species.
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Bases de dados:
MEDLINE
Assunto principal:
Coelhos
/
Variação Genética
/
Genes sry
Limite:
Animals
País/Região como assunto:
Europa
Idioma:
En
Revista:
Anim Genet
Assunto da revista:
GENETICA
/
MEDICINA VETERINARIA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Portugal