Molecular modeling, synthesis, and preliminary biological evaluation of glutathione-S-transferase inhibitors as potential therapeutic agents.
J Med Chem
; 48(19): 6084-9, 2005 Sep 22.
Article
em En
| MEDLINE
| ID: mdl-16162009
ABSTRACT
Changes in the GSH/GST system have been found to correlate with resistance to anticancer alkylating agents, presumably through accelerated detoxification of these drugs since some GSTs have been shown to catalyze the conjugation of GSH to specific antineoplastic agents. GSH-alkyl derivatives were designed by molecular modeling, synthesized, and tested as inhibitors of human GST-Pi.
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Bases de dados:
MEDLINE
Assunto principal:
Óxido de Etileno
/
Glutationa
/
Glutationa Transferase
Limite:
Humans
Idioma:
En
Revista:
J Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Itália