Asymmetric aza-Henry reactions from N-p-tolylsulfinylimines.
Org Lett
; 7(20): 4407-10, 2005 Sep 29.
Article
em En
| MEDLINE
| ID: mdl-16178545
ABSTRACT
[reaction see text] N-Sulfinylimines derived from aromatic or aliphatic aldehydes and ketones react with nitromethane and NaOH in a highly diastereoselective manner under mild conditions. In the presence of TBAF, the reaction rates are strongly increased and the stereoselectivity is inverted. This method provides enantiomerically pure beta-nitroamines derived from enolizable aldimines and ketimines, which so far are hardly accessible by aza-Henry reactions.
Buscar no Google
Bases de dados:
MEDLINE
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Espanha