Diversity and function of adaptive immune receptors in a jawless vertebrate.
Science
; 310(5756): 1970-3, 2005 Dec 23.
Article
em En
| MEDLINE
| ID: mdl-16373579
ABSTRACT
Instead of the immunoglobulin-type antigen receptors of jawed vertebrates, jawless fish have variable lymphocyte receptors (VLRs), which consist of leucine-rich repeat (LRR) modules. Somatic diversification of the VLR gene is shown here to occur through a multistep assembly of LRR modules randomly selected from a large bank of flanking cassettes. The predicted concave surface of the VLR is lined with hypervariable positively selected residues, and computational analysis suggests a repertoire of about 10(14) unique receptors. Lamprey immunized with anthrax spores responded with the production of soluble antigen-specific VLRs. These findings reveal that two strikingly different modes of antigen recognition through rearranged lymphocyte receptors have evolved in the jawless and jawed vertebrates.
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Bases de dados:
MEDLINE
Assunto principal:
Adaptação Biológica
/
Receptores Imunológicos
/
Imunidade
/
Lampreias
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos