Magnesium sulfate: role as possible attenuating factor in vasospasm morbidity.
Surg Neurol
; 65 Suppl 1: S1:14-1:20; discussion S1:20-1:21, 2006.
Article
em En
| MEDLINE
| ID: mdl-16427437
ABSTRACT
BACKGROUND:
Among the many complications of SAH, one of the most important is vasospasm. Several treatment alternatives have been proposed for this condition, with far-from-ideal results being obtained. Magnesium sulfate recently returned to the scene (with still unproven benefit) as an adjuvant in the treatment of vasospasm.METHODS:
Seventy-two patients diagnosed with SAH by aneurysm rupture were submitted to microsurgery craniotomy and subdivided in 2 groups. Group 1, formed by 48 patients, received prophylactic hypervolemic and hemodilution therapy in addition to nimodipine. Group 2, composed of 24 patients, received the same treatment of group 1 with the addition of magnesium sulfate in continuous infusion from 120 to 150 mg a day, keeping serum magnesium levels close to double normal values.RESULTS:
Age was 49 +/- 12.6 years. Ratio of female to male was 3.161. Most patients were admitted in a Hunt-Hess grade 2 (46.4%) and Fisher grade 3 (52.8%). Anterior communicating artery aneurysms were the most common in location (38.8%). Both groups were compared, and there was no statistical difference related to age, sex, and Glasgow, Fisher, or Hunt-Hess admission grades. No statistical difference in vasospasm incidence was found between the two groups. However, in group 1, vasospasm was correlated with a longer hospitalization time (P = .0003), different from group 2, in which patients with vasospasm receiving magnesium sulfate required less hospitalization time.CONCLUSION:
Magnesium did not seem to interfere in vasospasm frequency but apparently acted favorably in decreasing morbidity and length of hospital stay.
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Bases de dados:
MEDLINE
Assunto principal:
Bloqueadores dos Canais de Cálcio
/
Vasoespasmo Intracraniano
/
Sulfato de Magnésio
Tipo de estudo:
Clinical_trials
/
Etiology_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Surg Neurol
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Brasil