Chymase gene (CMA1) polymorphisms in Dutch and Japanese sarcoidosis patients.
Respiration
; 73(5): 623-33, 2006.
Article
em En
| MEDLINE
| ID: mdl-16446531
ABSTRACT
BACKGROUND:
Chymase is released from mast cells following activation. Evidence suggests that chymase plays an important role in tissue injury and remodeling of the lungs, heart and skin.OBJECTIVE:
We postulated that chymase gene (CMA1) polymorphisms are associated with pulmonary fibrosis in Dutch and with cardiac and skin involvement in Japanese sarcoidosis patients. PATIENTS ANDMETHODS:
Dutch (n = 153) and Japanese (n = 122) sarcoidosis patients with controls (Dutch, n = 309; Japanese, n = 111) were studied. Pulmonary involvement in Dutch patients as well as clinical manifestations in Japanese patients was evaluated for association with five CMA1 polymorphisms.RESULTS:
The CMA1 polymorphisms were not associated with disease susceptibility in either population, or with radiographic evolution in the Dutch or with cardiac or skin involvement in the Japanese patients. The -526 T allele was associated with a lower iVC in Dutch patients.CONCLUSIONS:
The CMA1 polymorphisms studied do not contribute to disease susceptibility in Japanese or Dutch sarcoidosis patients. CMA1 polymorphisms do not influence radiographic evolution in Dutch sarcoidosis patients, nor do they predispose to cardiac or skin involvement in Japanese patients. However, the association between CMA1 -526 C/T and iVC in the Dutch patients suggests that chymase may modify the functional outcome of pulmonary sarcoidosis.
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Bases de dados:
MEDLINE
Assunto principal:
Sarcoidose Pulmonar
/
Polimorfismo de Nucleotídeo Único
/
Povo Asiático
/
População Branca
/
Quimases
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
/
Europa
Idioma:
En
Revista:
Respiration
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Holanda