Respiratory rhythm generation during gasping depends on persistent sodium current.
Nat Neurosci
; 9(3): 311-3, 2006 Mar.
Article
em En
| MEDLINE
| ID: mdl-16474390
ABSTRACT
In severe hypoxia, homeostatic mechanisms maintain function of the brainstem respiratory network. We hypothesized that hypoxia involves a transition from neuronal mechanisms of normal breathing (eupnea) to a rudimentary pattern of inspiratory movements (gasping). We provide evidence for hypoxia-driven transformation within the central respiratory oscillator, in which gasping relies on persistent sodium current, whereas eupnea does not depend on this cellular mechanism.
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Bases de dados:
MEDLINE
Assunto principal:
Centro Respiratório
/
Relógios Biológicos
/
Tronco Encefálico
/
Canais de Sódio
/
Inalação
/
Rede Nervosa
Limite:
Animals
Idioma:
En
Revista:
Nat Neurosci
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Reino Unido