Effect of L-ascorbic acid on nickel-induced alterations in serum lipid profiles and liver histopathology in rats.
J Basic Clin Physiol Pharmacol
; 17(1): 29-44, 2006.
Article
em En
| MEDLINE
| ID: mdl-16639878
ABSTRACT
Nickel exposure greatly depletes intracellular ascorbate and alters ascorbate-cholesterol metabolism. We studied the effect of the simultaneous oral treatment with L-ascorbic acid (50 mg/100 g body weight (BW) and nickel sulfate (2.0 mg/100 g BW, i.p) on nickelinduced changes in serum lipid profiles and liver histopathology. Nickel-treated rats showed a significant increase in serum low-density lipoprotein-cholesterol, total cholesterol, triglycerides, and a significant decrease in serum high-density lipoprotein-cholesterol. In the liver, nickel sulfate caused a loss of normal architecture, fatty changes, extensive vacuolization in hepatocytes, eccentric nuclei, and Kupffer cell hypertrophy. Simultaneous administration of L-ascorbic acid with nickel sulfate improved both the lipid profile and liver impairments when compared with rats receiving nickel sulfate only. The results indicate that L-ascorbic acid is beneficial in preventing nickel-induced lipid alterations and hepatocellular damage.
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Bases de dados:
MEDLINE
Assunto principal:
Ácido Ascórbico
/
Metabolismo dos Lipídeos
/
Lipídeos
/
Fígado
/
Níquel
Limite:
Animals
Idioma:
En
Revista:
J Basic Clin Physiol Pharmacol
Assunto da revista:
FARMACOLOGIA
/
FISIOLOGIA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Índia