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Pharmaceutical care program for patients with uncontrolled hypertension. Report of a double-blind clinical trial with ambulatory blood pressure monitoring.
de Castro, Mauro Silveira; Fuchs, Flávio Danni; Santos, Melissa Costa; Maximiliano, Paulo; Gus, Miguel; Moreira, Leila Beltrami; Ferreira, Maria Beatriz Cardoso.
Afiliação
  • de Castro MS; Department of Drug Production and Control, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
Am J Hypertens ; 19(5): 528-33, 2006 May.
Article em En | MEDLINE | ID: mdl-16647628
BACKGROUND: Pharmaceutical care programs may be an option to improve blood pressure (BP) control in patients with uncontrolled hypertension. The aim of this study was to evaluate the efficacy of pharmaceutical care programs in treating patients with resistant hypertension. METHODS: In a double-blind randomized clinical trial, 71 patients with uncontrolled BP were enrolled in a pharmaceutical care program or in a control group and underwent a series of cognitive tests. The primary outcome was change in ambulatory BP (ABP) between the baseline evaluation and the final visit 6 months later. The secondary outcomes were the frequency of drug-related problems and adherence as determined by plasma levels of hydrochlorothiazide. RESULTS: The delta-values between the intervention and control groups for ABP in the different daily periods, with the corresponding 95% confidence limits, adjusted for age and baseline BP were: 3 (-1 to 5), 2 (-2 to 4), and 5 (-1 to 6) mm Hg for 24 h, daily and nightly systolic BP, respectively. The corresponding values for diastolic BP were 1 (-1 to 3), 0 (-2 to 2), and 3 (-1 to 4) mm Hg, respectively. Hydrochlorothiazide was detected in the plasma in 21 of 27 patients in the intervention group that attended to all appointments and 24 of 30 patients in the control group (P = .904). CONCLUSIONS: The pharmaceutical care program tested in this trial was feasible and showed a trend for better BP control in patients with uncontrolled hypertension.
Assuntos
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Bases de dados: MEDLINE Assunto principal: Assistência Farmacêutica / Pressão Sanguínea / Avaliação de Programas e Projetos de Saúde / Hipertensão / Anti-Hipertensivos Tipo de estudo: Clinical_trials / Evaluation_studies / Observational_studies / Prognostic_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Am J Hypertens Assunto da revista: ANGIOLOGIA Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Brasil
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Bases de dados: MEDLINE Assunto principal: Assistência Farmacêutica / Pressão Sanguínea / Avaliação de Programas e Projetos de Saúde / Hipertensão / Anti-Hipertensivos Tipo de estudo: Clinical_trials / Evaluation_studies / Observational_studies / Prognostic_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Am J Hypertens Assunto da revista: ANGIOLOGIA Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Brasil