Gene transfer approaches for gynecological diseases.
Mol Ther
; 14(2): 154-63, 2006 Aug.
Article
em En
| MEDLINE
| ID: mdl-16650808
ABSTRACT
Gene transfer presents a potentially useful approach for the treatment of diseases refractory to conventional therapies. Various preclinical and clinical strategies have been explored for treatment of gynecological diseases. Given the direst need for novel treatments, much of the work has been performed with gynecological cancers and ovarian cancer in particular. Although the safety of many approaches has been demonstrated in early phase clinical trials, efficacy has been mostly limited so far. Major challenges include improving gene transfer vectors for enhanced and selective delivery and achieving effective penetration and spread within advanced and complex tumor masses. This review will focus on current and developmental gene transfer applications for gynecological diseases.
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Bases de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
Terapia Genética
/
Doenças dos Genitais Femininos
/
Neoplasias dos Genitais Femininos
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Mol Ther
Assunto da revista:
BIOLOGIA MOLECULAR
/
TERAPEUTICA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Finlândia