Post-coital antifertility activity of Achyranthes aspera Linn. root.

ABSTRACT

Achyranthes aspera Linn. (Amaranthaceae) is an abundant indigenous herb in India. It is traditionally being used as an abortifacient. The ethanol extract of the root was screened for antifertility activity in proven fertile female albino rats at 200 mg/kg body weight and given orally on days 1-7 of pregnancy. The ethanol extract exhibited 83.3% anti-implantation activity when given orally at 200 mg/kg body weight. The rats, which continued their pregnancy, did not deliver any litters after their full term. Hence the combined antifertility (anti-implantation and abortifacient) activity of ethanol extract was 100%. The results suggest that the ethanol extract possess both anti-implantation and abortifacient activity. The ethanol extract also exhibited estrogenic activity tested in immature ovariectomised female albino rats. Histological studies were carried out to confirm this.