Pharmacological targeting of adipocytes/fat metabolism for treatment of obesity and diabetes.
Mol Pharmacol
; 70(3): 779-85, 2006 Sep.
Article
em En
| MEDLINE
| ID: mdl-16760360
ABSTRACT
Obesity is now recognized as a rapidly increasing worldwide threat to health, largely as a result of causing diabetes. Thus, considerable efforts are underway in the pharmaceutical industry to find drugs to treat this condition. Target validation in various academic and industrial laboratories has revealed a number of potential molecular targets in fat cells or adipocytes. By definition, obesity is too much fat, and we here review efforts to treat obesity and, by proxy, diabetes by modulating the metabolic state of adipocytes.
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Bases de dados:
MEDLINE
Assunto principal:
Adipócitos
/
Diabetes Mellitus Tipo 2
/
Metabolismo dos Lipídeos
/
Obesidade
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Mol Pharmacol
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos