Reduced IFN-alpha secretion by blood dendritic cells in human diabetes.
Clin Immunol
; 121(1): 81-9, 2006 Oct.
Article
em En
| MEDLINE
| ID: mdl-16859998
ABSTRACT
Characterization of dendritic cells (DC) in human diabetes has been restricted to monocyte-derived DC in type 1 diabetes, whose physiological relevance to endogenous DC is uncertain. Here, we provide the first report characterizing the phenotype and function of endogenous DC subsets in type 1 and type 2 diabetes. We show that DC subsets in each diabetic group exhibit normal properties concerning frequency and activation state, as determined using 4-color flow cytometry of whole blood cells. DC maturation is also intact as confirmed by their efficacious ability to stimulate T cell proliferation in an allogeneic MLR assay. Yet we found that DC are poor producers of IFN-alpha (P < 0.05) in human diabetes. IFN-alpha is a potent antiviral agent and therefore its reduced levels may interfere with T cell-mediated immune responses leading to increased susceptibility and persistence of infections in persons with diabetes.
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Bases de dados:
MEDLINE
Assunto principal:
Células Dendríticas
/
Interferon-alfa
/
Diabetes Mellitus Tipo 1
/
Diabetes Mellitus Tipo 2
Limite:
Adult
/
Humans
/
Middle aged
Idioma:
En
Revista:
Clin Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Canadá