In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457.
Antimicrob Agents Chemother
; 51(1): 361-5, 2007 Jan.
Article
em En
| MEDLINE
| ID: mdl-17101672
ABSTRACT
RWJ-416457, an investigational pyrrolopyrazolyl-substituted oxazolidinone, inhibited the growth of linezolid-susceptible staphylococci, enterococci, and streptococci at concentrations of < or =4 microg/ml, generally exhibiting two- to fourfold-greater potency than that of linezolid. Time-kill studies demonstrated bacteriostatic effects for both RWJ-416457 and linezolid.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Oxazolidinonas
/
Antibacterianos
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos