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HBcAg-specific CD4+CD25+ regulatory T cells modulate immune tolerance and acute exacerbation on the natural history of chronic hepatitis B virus infection.
Feng, I-Che; Koay, Lok-Beng; Sheu, Ming-Jen; Kuo, Hsing-Tao; Sun, Chi-Shu; Lee, Chuan; Chuang, Wong-Lung; Liao, Shuen-Kuei; Wang, Shih-Ling; Tang, Ling-Yu; Cheng, Chia-Ju; Tsai, Sun-Lung.
Afiliação
  • Feng IC; Hepatogastroenterology Section, Department of Internal Medicine, Chi Mei Medical Center, Yung-Kang City, Tainan, Taiwan.
J Biomed Sci ; 14(1): 43-57, 2007 Jan.
Article em En | MEDLINE | ID: mdl-17109186
ABSTRACT
Acute exacerbations (AEs) of chronic hepatitis B (CH-B) are accompanied by increased T cell responses to hepatitis B core and e antigens (HBcAg/HBeAg). Why patients are immunotolerant (IT) to the virus and why AEs occur spontaneously on the immunoactive phase remain unclear. The role of HBcAg-specific CD4(+)CD25(+) regulatory T (T(reg)) cells in AE and IT phases was investigated in this study. The SYFPEITHI scoring system was employed to predict MHC class II-restricted epitope peptides on HBcAg overlapping with HBeAg that were used for T(reg)-cell cloning and for the construction of MHC class II tetramers to measure T(reg) cell frequencies (T(reg) f). The results showed that HBcAg-specific T(reg) f declined during AE accompanied by increased HBcAg peptide-specific cytotoxic T lymphocyte frequencies. Predominant Foxp3-expressing T(reg) cell clones were generated from patients on the immune tolerance phase, while the majority of Th1 clones were obtained from patients on the immunoactive phase. T(reg) cells from liver and peripheral blood of CH-B patients express CD152 and PD1 antigens that exhibit suppression on PBMCs proliferation to HBcAg. These data suggest that HBcAg peptide-specific T(reg) cells modulate the IT phase, and that their decline may account for the spontaneous AEs on the natural history of chronic hepatitis B virus infection.
Assuntos
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Bases de dados: MEDLINE Assunto principal: Linfócitos T Reguladores / Hepatite B Crônica / Antígenos do Núcleo do Vírus da Hepatite B / Antígenos E da Hepatite B / Tolerância Imunológica Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Biomed Sci Assunto da revista: MEDICINA Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Taiwan
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Bases de dados: MEDLINE Assunto principal: Linfócitos T Reguladores / Hepatite B Crônica / Antígenos do Núcleo do Vírus da Hepatite B / Antígenos E da Hepatite B / Tolerância Imunológica Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Biomed Sci Assunto da revista: MEDICINA Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Taiwan