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Are there differences of inflammatory bio-markers between diabetic and non-diabetic patients with critical limb ischemia?
Bertz, L; Barani, J; Gottsäter, A; Nilsson, P M; Mattiasson, I; Lindblad, B.
Afiliação
  • Bertz L; Department of Vascular Diseases Malmö-Lund, Lund University, Malmö University Hospital, Malmö, Sweden.
Int Angiol ; 25(4): 370-7, 2006 Dec.
Article em En | MEDLINE | ID: mdl-17164743
AIM: This observational study was undertaken in order to analyse whether any differences could be detected between diabetic and non-diabetic patients with critical limb ischemia (CLI) concerning the inflammatory response. METHODS: A total number of 259 consecutive patients with CLI were treated between October 2001 and January 2003. RESULTS: Among the 259 patients, 135 (52%) had diabetes, previously known in 123, and detected during hospitalization in 12. The diabetic patients more often showed gangrene (P<0.05) and infra-inguinal atherosclerosis (84% vs 67%, P=0.001). The patients with diabetes showed a better lipid profile (total cholesterol 4.6 vs 5 mmol/L, P=0.006 and lower LDL-cholesterol (2.7 vs 3.1 mmol/L, P=0.010) despite the same frequency of statin treatment. They showed a higher creatinine (149 vs 117 micromol/L, P=0.0003) than the non-diabetic patients. Of the inflammatory markers, C-reactive protein (CRP) was equally elevated in both groups. Tumor necrosis factor-a (TNF-a) was increased among the diabetic patients (2.6 vs 1.8 pg/mL, P<0.05), and this difference was most evident in those with gangrene. Neopterin was also higher among the diabetic patients (31 vs 21 mmol/L, P<0.01), but CD40L was not different between groups. CONCLUSIONS: Diabetes mellitus was very common in CLI patients, and more often combined with renal impairment and infra-inguinal atherosclerosis. The inflammatory markers TNF-a and neopterin were elevated in patients with diabetes as compared to non-diabetic patients, but this difference cannot explain why CLI is 10 times more frequent in diabetic patients.
Assuntos
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Bases de dados: MEDLINE Assunto principal: Proteína C-Reativa / Interleucina-6 / Interferon-alfa / Angiopatias Diabéticas / Isquemia / Perna (Membro) Tipo de estudo: Observational_studies Limite: Aged / Female / Humans / Male Idioma: En Revista: Int Angiol Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Suécia
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Bases de dados: MEDLINE Assunto principal: Proteína C-Reativa / Interleucina-6 / Interferon-alfa / Angiopatias Diabéticas / Isquemia / Perna (Membro) Tipo de estudo: Observational_studies Limite: Aged / Female / Humans / Male Idioma: En Revista: Int Angiol Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Suécia