Terbutaline pharmacokinetics in cows: preliminary data.
Can J Vet Res
; 71(1): 70-3, 2007 Jan.
Article
em En
| MEDLINE
| ID: mdl-17193884
ABSTRACT
The objective of this study was to determine the serum pharmacokinetics of terbutaline in healthy cows. In the initial experiment, terbutaline was administered once as an intravenous (i.v.) bolus to 6 near-term pregnant beef cows within 24 h after parturition at a low but therapeutically relevant dose, 5 microg/kg. A 2nd experiment was conducted in the same cows with a higher dose, 0.5 mg/kg, but an otherwise similar experimental design. The serum concentration of terbutaline was determined by means of high-performance liquid chromatography with fluorescence detection in both experiments. After i.v. administration of 0.5 mg/kg, the mean peak serum concentration, residence time, and half-life were 708.22 (standard deviation 509.6) ng/mL, 6.75 (3.6) min, and 6.93 (2.4) min, respectively. The results indicate that terbutaline is rapidly eliminated from the bloodstream after i.v. administration in cattle, falling below the assay's limit of detection 30 min after administration.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Terbutalina
/
Tocolíticos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Can J Vet Res
Assunto da revista:
MEDICINA VETERINARIA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos