On the mechanism of inhibition of enzyme induction in Escherichia coli by distamycin A.
Farmaco Sci
; 30(11): 859-69, 1975 Nov.
Article
em En
| MEDLINE
| ID: mdl-172369
ABSTRACT
The mechanism of the interference of the antiviral antibiotic distamycin A with the bacterial cell has been investigated. Labelled distamycin A is firmly bound by E. coli cells and the binding process does not require metabolic energy as indicated by the use of inhibitors. The antibiotic does not induce gross alteration in the cell membrane but inhibits cyclic AMP accumulation in the cells exposed to a glucose-free medium. This inhibition is concomitant with that exerted on the synthesis of an inducible enzyme such as beta-galactosidase. By the method of pulse induction it appears that distamycin A exterts its inhibiting effect on inducible synthesis at the level of transcription. This effect is probably related to an interference with the positive control of enzyme synthesis performed via the system represented by cyclic AMP and the CRP protein.
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Bases de dados:
MEDLINE
Assunto principal:
Pirróis
/
Indução Enzimática
/
Distamicinas
/
Escherichia coli
Idioma:
En
Revista:
Farmaco Sci
Ano de publicação:
1975
Tipo de documento:
Article