Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations.
Biochem Biophys Res Commun
; 355(1): 41-6, 2007 Mar 30.
Article
em En
| MEDLINE
| ID: mdl-17292328
ABSTRACT
Recently, neuroligins (NLs)3 and 4X have received much attention as autism-related genes. Here, we identified syntrophin-gamma2 (SNTG2) as a de novo binding partner of NL3. SNTG2 also bound to NL4X and NL4Y. Interestingly, the binding was influenced by autism-related mutations, implying that the impaired interaction between NLs and SNTG2 contributes to the etiology of autism.
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Bases de dados:
MEDLINE
Assunto principal:
Transtorno Autístico
/
Proteínas de Transporte
/
Proteínas de Membrana
/
Proteínas Musculares
/
Mutação
/
Proteínas do Tecido Nervoso
Limite:
Humans
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Japão