Holotranscobalamin and methylmalonic acid as prognostic markers following an acute myocardial infarction.
Eur J Clin Nutr
; 62(3): 411-8, 2008 Mar.
Article
em En
| MEDLINE
| ID: mdl-17342163
ABSTRACT
OBJECTIVE:
To evaluate whether low levels of holotranscobalamin (holoTC) or elevated levels of methylmalonic acid (MMA), both indicators of vitamin B(12) deficiency, might predispose to new cardiovascular events following an acute myocardial infarction (MI).DESIGN:
A prospective prognostic study.SETTING:
One hospital center in Stavanger, Norway.SUBJECTS:
A total of 300 patients admitted with an acute MI.METHODS:
Registration of new TnT positive coronary events (defined as TnT>0.05 microg/l and a typical MI pattern) and/or cardiac death during a median follow-up time of 45 months.RESULTS:
We compared the recurrence of events in the lowest quartile of holoTC (Q1<73.9 pmol/l) to the event rate above the 25% percentile (Q2-4). For methylmalonic acid (MMA) the same comparison was carried out for the upper quartile (Q4 > or =0.24 micromol/l) as compared with the event rate below the 75% percentile (Q1-3). After 18 and 45 months of follow-up, the odds ratio (OR) for Q1 vs Q2-4 for holoTC was 1.15 (95% confidence interval (CI) 0.91-1.46, P=0.25) and 1.05 (95% CI 0.86-1.29, P=0.64), respectively. For MMA the OR for Q4 vs Q1-3 was 0.95 (95% CI 0.76-1.19, P=0.67) after 18 months and 1.01 (95% CI 0.83-1.23, P=0.90) after 45 months.CONCLUSION:
This study showed no increased risk of future cardiovascular events associated with low levels of holoTC or high levels of MMA following an acute MI.
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Bases de dados:
MEDLINE
Assunto principal:
Deficiência de Vitamina B 12
/
Transcobalaminas
/
Ácido Metilmalônico
/
Infarto do Miocárdio
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Eur J Clin Nutr
Assunto da revista:
CIENCIAS DA NUTRICAO
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Noruega