Design of simulated moving bed processes under reduced purity requirements.
J Chromatogr A
; 1162(1): 2-13, 2007 Aug 24.
Article
em En
| MEDLINE
| ID: mdl-17400238
ABSTRACT
The design of simulated moving bed chromatography under reduced purity requirements is investigated. A parametric study indicates that all internal flow rates should be considered as free parameters in process design. This is confirmed by systematic numerical optimisations of two different design scenarios. A restrictive scenario requires complete regeneration of liquid and solid phases. In contrast, in a non-restrictive design all flow rates are optimised. The latter leads to significantly improved process performance. On the basis of the obtained observations, a simple design method for simulated moving bed processes with desired outlet purity values is derived from equilibrium theory.
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Bases de dados:
MEDLINE
Assunto principal:
Solventes
/
Cromatografia em Gel
/
Cromatografia Líquida
/
Tecnologia Farmacêutica
Tipo de estudo:
Evaluation_studies
Idioma:
En
Revista:
J Chromatogr A
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Alemanha