The endocannabinoid system and neurogenesis in health and disease.
Neuroscientist
; 13(2): 109-14, 2007 Apr.
Article
em En
| MEDLINE
| ID: mdl-17404371
ABSTRACT
The endocannabinoid system exerts an important neuromodulatory function in different brain areas and is also known to be involved in the regulation of neural cell fate. Thus, CB(1) cannabinoid receptors are neuroprotective in different models of brain injury, and their expression is altered in various neurodegenerative diseases. Recent findings have demonstrated the presence of a functional endocannabinoid system in neural progenitor cells that participates in the regulation of cell proliferation and differentiation. In this Research Update, the authors address the experimental evidence regarding the regulatory role of cannabinoids in neurogenesis and analyze them in the context of those pathological disorders in which cannabinoid function and altered neuronal or glial generation is most relevant, for example, stroke and multiple sclerosis.
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Bases de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Encefalopatias
/
Receptor CB1 de Canabinoide
/
Endocanabinoides
/
Proliferação de Células
/
Moduladores de Receptores de Canabinoides
/
Regeneração Nervosa
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Neuroscientist
Assunto da revista:
NEUROLOGIA
/
PSIQUIATRIA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Espanha