Effects of imipramine on extracellular serotonin and noradrenaline concentrations in ACTH-treated rats.
Eur J Pharmacol
; 566(1-3): 113-6, 2007 Jul 02.
Article
em En
| MEDLINE
| ID: mdl-17459373
ABSTRACT
We investigated the effect of imipramine on extracellular serotonin (5-HT) and noradrenaline concentrations in the medial prefrontal cortex of rats treated with adrenocorticotropic hormone (ACTH) for 14 days using in vivo microdialysis. Chronic ACTH treatment did not affect basal extracellular 5-HT and noradrenaline concentrations compared with chronic saline treatment. Acute imipramine treatment plus chronic ACTH treatment significantly increased extracellular 5-HT concentrations, compared with imipramine treatment alone. 8-hydroxy-2-di-n-propylamino tetralin (8-OH-DPAT), a 5-HT1A receptors full agonist, caused a significant decrease in extracellular 5-HT concentrations. However, its inhibitory effect was attenuated by the treatment with ACTH for 14 days. These findings suggest that chronic treatment with ACTH enhances the increasing effect release of 5-HT by imipramine through the desensitization of somatodendritic 5-HT1A autoreceptors.
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Bases de dados:
MEDLINE
Assunto principal:
Serotonina
/
Córtex Pré-Frontal
/
Hormônio Adrenocorticotrópico
/
Inibidores da Captação Adrenérgica
/
Imipramina
/
Antidepressivos Tricíclicos
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Japão