Maternal alcohol and coffee drinking, parental smoking and childhood leukaemia: a French population-based case-control study.
Paediatr Perinat Epidemiol
; 21(4): 293-9, 2007 Jul.
Article
em En
| MEDLINE
| ID: mdl-17564585
ABSTRACT
We investigated the role of maternal alcohol and coffee drinking during pregnancy and that of parental smoking in the aetiology of childhood leukaemia. A French, population-based, case-control study was conducted, comparing 472 [407 acute lymphoblastic leukaemia (ALL) and 62 acute myeloblastic leukaemia] cases of childhood acute leukaemia (AL) and 567 population controls, frequency-matched with cases on age, gender and region of residence. Both case and control mothers filled in a comprehensive self-administered standardised questionnaire, eliciting detailed data on maternal alcohol and coffee consumption during pregnancy and parental smoking before, during and after pregnancy. Maternal alcohol consumption of more than 1 drink per day was related to ALL (OR = 2.8 [95% CI 1.8, 5.9]). While maternal coffee consumption was not significantly related to AL (OR = 1.4 [95% CI 0.9, 2.3]), highest intake of coffee (more than 3 cups per day) during pregnancy was associated with AL in children whose mothers were non-smokers (OR = 1.9 [95% CI 1.0, 3.5]). No association with parental smoking, either maternal or paternal, was observed with AL. The present results suggest a possible role of the highest consumption of alcohol by the mother during pregnancy in the aetiology of childhood AL.
Buscar no Google
Bases de dados:
MEDLINE
Assunto principal:
Cafeína
/
Consumo de Bebidas Alcoólicas
/
Leucemia Mieloide Aguda
/
Fumar
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Estimulantes do Sistema Nervoso Central
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Pregnancy
País/Região como assunto:
Europa
Idioma:
En
Revista:
Paediatr Perinat Epidemiol
Assunto da revista:
EPIDEMIOLOGIA
/
PEDIATRIA
/
PERINATOLOGIA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
França