Lost in the world of functional genomics, systems biology, and translational research: is there life after the Milstein award?
Cytokine Growth Factor Rev
; 18(5-6): 441-50, 2007.
Article
em En
| MEDLINE
| ID: mdl-17681845
ABSTRACT
We have always wanted to save the world from the scourges of virus infection by developing better drugs and vaccines. But fully understanding the intricacies of virus-host interactions, the first step in achieving this goal, requires the ability to view the process on a grand scale. The advent of high-throughput technologies, such as DNA microarrays and mass spectrometry, provided the first opportunities to obtain such a view. Here, we describe our efforts to use these tools to focus on the changes in cellular gene expression and protein abundance that occur in response to virus infection. By examining these changes in a comprehensive manner, we have been able to discover exciting new insights into innate immunity, interferon and cytokine signaling, and the strategies used by viruses to overcome these cellular defenses. Functional genomics may yet save the world from killer viruses.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Vírus
/
Genômica
/
Interações Hospedeiro-Patógeno
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cytokine Growth Factor Rev
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
BIOQUIMICA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos