Effects of amlodipine, captopril, and bezafibrate on oxidative milieu in rats with fatty liver.
Dig Dis Sci
; 53(3): 777-84, 2008 Mar.
Article
em En
| MEDLINE
| ID: mdl-17710547
ABSTRACT
Oxidative stress may initiate significant hepatocyte injury in subjects with fatty liver. We characterized changes in hepatic oxidative anti-oxidative parameters in rats given a fructose-enriched diet (FED) with and without medications to reduce blood pressure or plasma triglycerides. FED rats had an increase in malondialdehyde (MDA) concentration, a reduction in alpha-tocopherol concentration, a reduction in paraoxonase (PON) activity, an increase in glutathione peroxidase (GSH-Px), and glutathione reductase (GSSG-R) activity. Amlodipine increased PON and GSH-Px, but decreased GSSG-R activity and alpha-tocopherol concentration. Captopril decreased MDA concentration and the activity of both GSH-Px and GSSG-R, but increased alpha-tocopherol concentration and PON activity. Bezafibrate increased alpha-tocopherol concentration and PON activity, but decreased the activity of GSSG-R. Animals with fatty liver exhibit an increase in peroxidative stress but also a defect in anti-oxidative pathways. Drugs administered to treat hypertension and hypertriglyceridemia could lead to a variety of changes in the hepatic oxidative, anti-oxidative milieu.
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Bases de dados:
MEDLINE
Assunto principal:
Estresse Oxidativo
/
Fígado Gorduroso
/
Frutose
/
Anti-Hipertensivos
/
Hipolipemiantes
Limite:
Animals
Idioma:
En
Revista:
Dig Dis Sci
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Israel