Human endometrium mRNA profile assessed by oligonucleotide three-dimensional microarray.
Gynecol Endocrinol
; 23(9): 527-34, 2007 Sep.
Article
em En
| MEDLINE
| ID: mdl-17852415
ABSTRACT
Our purpose, in the present work, was to further comprehend the genetic events underlying the response to steroids of human endometrium from the mRNA as well as protein expression point of view. In order to achieve this goal we undertook 10,000-oligonucleotide, three-dimensional microarray analysis, followed by immunohistochemistry, on human normal endometrium in the proliferative and secretory phases of the menstrual cycle. The results revealed that a myriad of genes involved in immune response, calcium metabolism and thyroid hormone response were frequently overexpressed in the second or luteal phase of the menstrual cycle. During the follicular phase, in contrast, overexpression of genes was mainly restricted to those encoding proteins involved in cell proliferation.
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Bases de dados:
MEDLINE
Assunto principal:
RNA Mensageiro
/
Análise de Sequência com Séries de Oligonucleotídeos
/
Endométrio
Limite:
Female
/
Humans
Idioma:
En
Revista:
Gynecol Endocrinol
Assunto da revista:
ENDOCRINOLOGIA
/
GINECOLOGIA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Brasil