Autologous stem cell transplantation for severe autoimmune diseases: a 10-year experience.
Ann N Y Acad Sci
; 1110: 455-64, 2007 Sep.
Article
em En
| MEDLINE
| ID: mdl-17911461
ABSTRACT
The first autologous hematopoietic stem cell transplantation in Europe for a patient with severe refractory systemic lupus erythematosus (SLE) was performed in Genoa in 1996. Since then, 32 patients with a wide spectrum of autoimmune diseases (ADs) received autologous transplants, 22 of them with multiple sclerosis (MS). There were no fatal adverse events. All patients had complete or very good partial remissions, but relapses were frequent, especially in SLE, though never as aggressive as pretransplant. The mechanism of action of this intervention remains not completely understood, as briefly discussed here.
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Bases de dados:
MEDLINE
Assunto principal:
Transplante de Células-Tronco
/
Lúpus Eritematoso Sistêmico
/
Esclerose Múltipla
Limite:
Humans
Idioma:
En
Revista:
Ann N Y Acad Sci
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Itália