Multicentric Castleman disease with secondary AA renal amyloidosis, nephrotic syndrome and chronic renal failure, remission after high-dose melphalan and autologous stem cell transplantation.
Clin Nephrol
; 68(3): 171-6, 2007 Sep.
Article
em En
| MEDLINE
| ID: mdl-17915620
ABSTRACT
Multicentric Castleman disease is a systemic lymphoproliferative disease with incomplete understood etiology. The various renal complications of this disease may include minimal change disease, mesangial proliferative glomerulonephritis, membranous glomerulonephritis and nephrotic syndrome, caused by secondary amyloidosis. In several reported cases of localized Castleman disease associated with renal amyloidosis and nephrotic syndrome, resection of organs involved by lymphoid proliferation resulted in complete remission. However, therapy of multicentric Castleman disease with renal amyloidosis is not well-established. We treated a case of a 39-year-old woman with multicentric Castleman disease complicated by nephrotic syndrome caused by secondary AA amyloidosis. The patient underwent autologous peripheral blood stem cell transplantation (auto-PBSCT), achieving complete remission. Autologous stem cell transplantation may be an attractive choice in therapy for refractory multicentric Castleman disease.
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Bases de dados:
MEDLINE
Assunto principal:
Hiperplasia do Linfonodo Gigante
/
Amiloidose
/
Falência Renal Crônica
/
Síndrome Nefrótica
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Clin Nephrol
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Japão