Natural Tregs, CD4+CD25+ inhibitory hybridomas, and their cell contact dependent suppression.
Immunol Res
; 39(1-3): 62-78, 2007.
Article
em En
| MEDLINE
| ID: mdl-17917056
ABSTRACT
The natural CD4+CD25+ T regulatory (Treg) lymphocyte has emerged as a critical cell for controlling immune responses to self, foreign proteins, and pathogens. Identified initially by the constitutive expression of CD4 and CD25, natural Tregs suppress a variety of immune cells and responses, including CD4+CD25- proliferation and IL-2 production, and CD8 cell proliferation, IFNgamma production and CTL activity. Although natural Tregs require activation with specific antigen to attain their suppressive phenotype, once activated they execute inhibition in an antigen specific as well as non-specific (bystander) fashion. Treg suppression depends on IL-2, CD25, and cellcell contact. The use of live cell imaging in vivo and in vitro to visualize the dynamic cellcell interactions involving natural Tregs as well as the CD4+CD25+ Treg inhibitory hybridoma RD6 has refined the mechanistic models of contact dependent Treg suppression.
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Bases de dados:
MEDLINE
Assunto principal:
Receptores de Interleucina-2
/
Linfócitos T Reguladores
/
Tolerância Imunológica
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Immunol Res
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos