Growth inhibition of medullary thyroid carcinoma cells by pyrazolo-pyrimidine derivates.
J Endocrinol Invest
; 30(10): RC31-4, 2007 Nov.
Article
em En
| MEDLINE
| ID: mdl-18075281
ABSTRACT
There is no effective treatment for recurrent or metastatic medullary thyroid carcinoma (MTC), a tumor arising from thyroid C-cells commonly presenting an inherited or acquired RET mutation. In this study we examined the sensitivity of two human MTC cell lines to novel pyrazolopyrimidine derivates, able to inhibit src-family tyrosine kinase activity. In TT cells [carrying the multiple endocrine neoplasia (MEN)2A Ret mutation Cys 634Trp] and MZ-CRC-1 cells (carrying the MEN2B RET mutation Met891Thr), one of these compounds, namely Si 34, determined a significant growth inhibitory effect (approximately 90% vs control for TT, 80% vs control for MZ-CRC-1) mainly due to enhanced cell mortality after a 6-day incubation. At concentrations that increased cell mortality, neither biochemical or morphological characteristics of apoptosis were detected in TT and MZCRC- 1 cells treated with Si 34. These results, when confirmed in other in vivo preclinical models, suggest that this novel tyrosine kinase inhibitor may be useful for the treatment of MTC.
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Bases de dados:
MEDLINE
Assunto principal:
Pirazóis
/
Pirimidinas
/
Neoplasias da Glândula Tireoide
/
Carcinoma Medular
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
J Endocrinol Invest
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Itália