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Prognostic role of serum cytokeratin 19 fragments in advanced non-small-cell lung cancer: association of marker changes after two chemotherapy cycles with different measures of clinical response and survival.
Nisman, B; Biran, H; Heching, N; Barak, V; Ramu, N; Nemirovsky, I; Peretz, T.
Afiliação
  • Nisman B; Department of Oncology, Hadassah University Hospital, Jerusalem, Israel. nisman@hadassah.org.il
Br J Cancer ; 98(1): 77-9, 2008 Jan 15.
Article em En | MEDLINE | ID: mdl-18087272
Prognostic implication of serum cytokeratin 19 fragments (CYFRA 21-1) was explored in 60 advanced NSCLC patients, whereas in 45 patients assessable for serological response a >or=35% CYFRA 21-1 decline after two chemotherapy cycles was strongly associated with non-progression (NP), defined as a sum of objective response (OR)+stable disease (P<0.0001) and survival (P=0.0002). Association of OR with survival was not significant. In multivariate survival analysis, >or=35% marker decline and radiological NP status were found as major determinants of prolonged survival with RR: 0.37 (P=0.01) and 0.63 (P=0.01), respectively. In advanced NSCLC patients, NP reflects therapeutic efficacy better than traditional OR. CYFRA 21-1 >or=35% decline seems to be a reliable surrogate marker of treatment efficacy in terms of survival.
Assuntos

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Biomarcadores Tumorais / Carcinoma Pulmonar de Células não Pequenas / Queratinas / Neoplasias Pulmonares / Antígenos de Neoplasias Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Cancer Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Israel

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Biomarcadores Tumorais / Carcinoma Pulmonar de Células não Pequenas / Queratinas / Neoplasias Pulmonares / Antígenos de Neoplasias Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Cancer Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Israel