Expression and regulation of major histocompatibility complex on neural stem cells and their lineages.
Stem Cells Dev
; 17(1): 53-65, 2008 Feb.
Article
em En
| MEDLINE
| ID: mdl-18230026
ABSTRACT
The expression of major histocompatibility complex (MHC) antigens on neural stem cells (NSCs) and their lineages is tightly related to the fate of these cells as grafts in allogenic transplantation. In this study, we observed that NSCs derived from embryonic rat forebrain expressed MHC class I and class II molecules at a low level, whereas the cells differentiated from NSCs, including neurons, astrocytes, and oligodendrocytes, lost their MHC expression. However, a proinflammatory factor, interferon-gamma (IFN-gamma), could induce and up-regulate the expression of MHC in both NSCs and their differentiated lineages in vitro. These results suggest that predifferentiating NSCs into lineage-limited cells prior to transplantation combined with controlling the local production of proinflammatory cytokines moderately may potentially benefit the survival of transplants.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Células-Tronco
/
Complexo Principal de Histocompatibilidade
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
Stem Cells Dev
Assunto da revista:
HEMATOLOGIA
Ano de publicação:
2008
Tipo de documento:
Article