Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells.
J Immunol
; 180(5): 2752-6, 2008 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-18292493
ABSTRACT
The cytokine IL-27 is important for restricting inflammation in response to a wide variety of immune challenges. In this study, we demonstrate that IL-27 induces expression of the anti-inflammatory cytokine IL-10 by CD4+ and CD8+ T cells. IL-27 relied upon the Th1 transcription factor STAT1 to induce IL-10+IFN-gamma+FoxP3- Th1 cells, which were recently shown to be key negative regulators during certain infections. Il27ra-/- mice generated fewer IL-10+ T cells during both Listeria monocytogenes infection and experimental autoimmune encephalomyelitis. The data presented here indicate a novel mechanism for the induction of IL-10 expression by T cells and provide a mechanistic basis for the suppressive effects of IL-27.
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Bases de dados:
MEDLINE
Assunto principal:
Linfócitos T CD4-Positivos
/
Interleucinas
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Interleucina-10
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Linfócitos T CD8-Positivos
/
Fatores de Transcrição Forkhead
Limite:
Animals
Idioma:
En
Revista:
J Immunol
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos