Specific pathogen-free macaques: definition, history, and current production.
ILAR J
; 49(2): 137-44, 2008.
Article
em En
| MEDLINE
| ID: mdl-18323576
ABSTRACT
Specific pathogen-free (SPF) macaque colonies are now requested frequently as a resource for research. Such colonies were originally conceived as a means to cull diseased animals from research-dedicated colonies, with the goal of eliminating debilitating or fatal infectious agents from the colony to improve the reproductive capacity of captive research animals. The initial pathogen of concern was Mycobacterium tuberculosis (M.tb.), recognized for many years as a pathogen of nonhuman primates as well as a human health target. More recently attention has focused on four viral pathogens as the basis for an SPF colony simian type D retrovirus (SRV), simian immunodeficiency virus (SIV), simian T cell lymphotropic/leukemia virus (STLV), and Cercopithecine herpesvirus 1 (CHV-1). New technologies, breeding, and maintenance schemes have emerged to develop and provide SPF primates for research. In this review we focus on the nonhuman primates (NHPs) most common to North American NHP research facilities, Asian macaques, and the most common current research application of these animals, modeling of human AIDS.
Buscar no Google
Bases de dados:
MEDLINE
Assunto principal:
Organismos Livres de Patógenos Específicos
/
Macaca
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
ILAR J
Assunto da revista:
MEDICINA VETERINARIA
/
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos