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Structural basis for HLA-A2 supertypes.

Kangueane, Pandjassarame; Sakharkar, Meena Kishore.
Methods Mol Biol ; 409: 155-62, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-18449998
The human leukocyte antigen (HLA) alleles are extremely polymorphic among ethnic population, and the peptide-binding specificity varies for different alleles in a combinatorial manner. However, it has been suggested that majority of alleles can be covered within few HLA supertypes, where different members of a supertype bind similar peptides, yet exhibiting distinct repertoires. Nonetheless, the structural basis for HLA supertype-like function is not clearly known. Here, we use structural data to explain the molecular basis for HLA-A2 supertypes.